Alendronate Sodium

[Chemical Name]:

(4-Amino-1-hydroxy-1-phosphono-butyl)-phosphonic acid sodium salt trihydrate

[Description]:

Alendronate sodium is an oral aminobiphoshphante which has been approved in Australia for the treatment of established osteoporosis in post-menopausal women, and is also indicated for the treatment of Paget's disease of the bone.

Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. The empirical formula of alendronate sodium is C₄H₁₂NNaO₇P₂.3H₂O and its formula weight is 325.12.

Alendronate sodium is a white, crystalline, nonhygroscopic powder. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform.

[Structure]:

[Formula]: C₄H₁₂NNaO₇P₂.3H₂O

[Molecular weight]: 325.12

[CASRN]: 121268-17-5

[Specification]: USP28