ENALAPRIL MALEATE INTERMEDIATES

[Chemical Name]: (aS,4S)-4-Methyl-2,5-dioxo-a-(2-phenylethyl)-3-oxazolidineaceticacid, ethyl ester

[Synonyms]: Ethyl (S)-2-[(S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutyrate

[Structure]:

[Formula]: C16H19NO5

[Molecular Weight]: 305.33

[CAS RN]: 84793-24-8

[Density]: 1.223 g/ cm3

[Optical Rotation]: [a]20D = +36.5(HCCl3, c 1.00)

[Specification]:

Appearance White crystalline powder
Solubility Freely soluble in acetone acetonitrile
Specific rotation +36.5°(HCCl3, c 1.00)
Melting point 68~72℃
Loss on drying 0.5%max
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine 1.0%max
Cyclohexyl analog of alanine 0.3%max
Total unknown impurities 2.0%max
Purity HPLC 98.0%min